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Trulicity is under fire for causing people to lose their eyesight, suffer from pancreatitis, and be hospitalized for a slowed or paralyzed gut

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In the isolated perfused rat pancreas, co-infusion of GLP-1 with a specific somatostatin receptor 2 (SSTR2) antagonist (PRL-2903) abolishes the GLP-1-induced suppression of glucagon secretion [582]

This broader tissue distribution is particularly relevant for researchers designing cell-type-specific binding or functional assays, as the off-target receptor panel for retatrutide is wider than for either semaglutide or tirzepatide