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To approach the efficacy of BS, dual and triple agonists combining GLP-1 with other entero-pancreatic hormones with complementary actions, including glucose-dependent insulinotropic polypeptide (GIP), glucagon (GCG) and amylin are currently under development [15]

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This celebrated result was followed in 1983 by the work of Graeme Bell and colleagues at the Chiron Corporation (California), who cloned hamster and human cDNAs encoding preproglucagon [34, 35]