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Examples could include: Metformin combined with Wegovy Zepbound combined with another glucose-management medication Multiple GLP-1 agents prescribed together In these situations, AMEs are generally required to defer the application to the FAA for possible Special Issuance (SI) consideration

These effects vary from patient to patient, but understanding them allows for better management of semaglutide treatment and ensures that any gastrointestinal issues are identified and addressed early

Five clinical trials in type 2-diabetic subjects (SURPASS 15) have shown that the GLP-1/GLP agonist at 515 mg per week reduces both HbA1c (1.24 to 2.58%) and body weight (5.411.7 kg) by amounts unprecedented for a single agent

PlexusDx encourages patients to test different times during their first two weeks and stick with whichever approach feels most manageable

For example, a study published in JAMA Network Open found that patients lost approximately 5.9% of their body weight at 3 months and 10.9% at 6 months