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A small study found that limiting allulose consumption to about 20-30 grams at a time and 40 grams per day prevented these issues

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The study involved 48 individuals with signs of alcohol-use disorder who were not actively seeking treatment

Metformin, the current first-line treatment in T2DM, has an unclear antidepressant effect [166] despite identified direct mechanisms and pleiotropic effects, including inhibition of angiotensin II and NF-B factor, normalization of gut microbiota, and intestinal permeabilization, and in vivo experimental data [167] supporting its potential benefits