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Another big consideration is that people who have been on GLP-1s tend to gain more weight during pregnancy than those who have never taken the medications

For many, the weight comes back

Research published in the Annals of Pharmacotherapy confirms that none of the 25 topically applied products examined listed semaglutide, tirzepatide, or another FDA-approved GLP-1 agonist as an active ingredient

Fatigue usually improves over time as your body adapts to the GLP-1 medication, but persistent symptoms should be discussed with a healthcare provider

Also, several studies lacked full disclosure of variance measures or raw data, preventing the inclusion of potentially relevant findings