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Novo Nordisks #Semaglutide #Fails in #Alzheimers #EVOKE #Trials Show #No #Cognitive #Benefit Despite Biomarker Signals A highly anticipated moment at #ADPD2026 delivered a sobering outcome: Oral semaglutide failed to improve cognition or function in early Alzheimers EVOKE & EVOKE+ trials showed no difference vs placebo at 104 weeks Yet biomarker changes (#pTau181 ~10%) were observed Key findings from EVOKE / EVOKE+ 1 No clinical efficacy Primary endpoint (CDR-SB): no improvement Secondary endpoints (ADCS-ADL, MMSE, ADAS-Cog): no signal No delay in MCI Alzheimers progression 2 Biomarker disconnect CSF p-tau181 reduced (~10%) But no translation into clinical benefit 3 No responder subgroup No efficacy signal across age, BMI, T2D, sex, or race Why this matters 1 GLP-1 hype meets neurological reality Metabolic success neurodegenerative success Mechanisms dont simply transfer across disease domains 2 Biomarkers outcomes Even statistically significant changes May still be clinically meaningless 3 Rethinking Alzheimers biology Amyloid/tau biomarkers may not capture full disease complexity Especially for non-amyloid mechanisms 4 Strategic implications Expanding GLP-1 into CNS now looks riskier Pipeline prioritization will shift toward target-specific neurobiology My takeaway 1 The Alzheimers field still lacks validated translational endpoints 2 Biomarker-driven optimism must be matched with clinical reality 3 Cross-indication drug expansion requires mechanistic precisionnot trend following Bottom line: Novo Nordisks setback highlights a critical truth In Alzheimers, biology is still king and shortcuts dont work #Alzheimers #ADPD2026 #DrugDevelopment #Biotech #Neuroscience #GLP1 #ClinicalTrials A meaningful reality check for the field

Schumer then went on to describe how she had more recently used the telehealth provider Midi Health to receive hormone treatment for perimenopause as well as being prescribed Mounjaro for weight loss

Patients with a history of pancreatitis should discuss this risk with their provider

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Furthermore, there was no longer intraretinal fluid on OCT, but we observed diffuse thinning of the GCL in OD