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[Google Scholar] 199.Nguyen H-N, et al

How much weight can I lose on GLP-1 medication

Baxter S

Network meta-analyses demonstrate a progressive efficacy gradient: GLP-1 monotherapy achieves approximately 7 kg weight reduction, dual agonists reach 11 kg, while triple agonists achieve up to 24 kg weight loss at 52 weeks [77]

The rapid renal clearance of many small peptides like GLP-1, together with its inactivation by DPP4, required development of longer-acting peptides with greater stability and enhanced resistance to DPP-4
