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The semaglutide and tirzepatide trials changed that expectation: Semaglutide 2.4 mg once weekly produced average weight loss around 15% at ~68 weeks in adults without diabetes, with a substantial fraction of participants losing 1520% of baseline weight
If validated in adequately powered human trials, this would be a genuinely new mechanism for substance use disorders, rooted in metabolic signalling rather than monoamine modulation

GIP as a potential therapeutic target for atherosclerotic cardiovascular disease-a systematic review

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For a 200-pound person, that translates to 30 to 34 pounds
