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Dose-response effects on HbA1c and bodyweight reduction of survodutide, a dual glucagon/GLP-1 receptor agonist, compared with placebo and open-label semaglutide in people with type 2 diabetes: a randomised clinical trial

In 17,604 adults with overweight or obesity and established cardiovascular disease but no diabetes, semaglutide 2.4 mg cut the risk of major adverse cardiovascular events (heart attack, stroke, or cardiovascular death) by 20 percent over a mean follow-up of 39.8 months [9]