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Description
This parallels the early worsening phenomenon documented with intensive insulin therapy in landmark trials like DCCT, where temporary deterioration was followed by long-term benefits with sustained glycemic control 47
That said, there are edge cases
There is no reliable way to test potency at home, so your results will tell you whether the peptide is still effective
Additionally, concurrent use with other GLP-1 receptor agonists is not recommended due to duplicative therapy
Markers of apoptosis, such as CK-18, have been studied, but may not accurately reflect change in histology over time
