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For those currently using or considering using GLP-1 medications, it can be confusing and frustrating to have multiple studies with differing and sometimes conflicting findings around a potential risk to eye health and vision

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Furthermore, given that calorie restriction-induced AMPK activation stimulates Nampt transcription [94], and metformin, an AMPK activator, activates intestinal AMPK [93,106,107,108], the effects of metformin administration on Nampt expression and GLP-1 production should be comprehensively tested in HFD-fed obese mice with impaired intestinal NAMPT-mediated NAD + biosynthesis [31]