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Cumulative Effect Over Time Sometimes, a rash might develop not immediately but after prolonged use of semaglutide

Moreover, newer GLP-1 RAs and the long half-life of dual agonists (up to 7 days for Semaglutide) give rise to longer preoperative fasting period requirements and concerns of perioperative management of patients, even in case of treatment interruption [1517]

Association of metabolic-bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants

doi: 10.1210/endo.133.6.8243312

While this has not been observed in humans, it remains a theoretical risk, and patients with a history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) are typically advised against using Semaglutide