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Retrieved from Christensen, M., Vedtofte, L., Holst, J

While the number of blockbusters (asset-indications forecast to achieve peak sales greater than $1 billion) has decreased to 108 in 2025, down from 111 in 2024, the number of mega-blockbusters (asset-indications forecasts to achieve peak sales greater than $10 billion) has increased from six in 2024 to eight in 2025

Its endogenous levels decline with age, which has made it a subject of interest in cellular and tissue biology research particularly in laboratory models exploring how copper-peptide signalling relates to repair and remodeling processes at the cellular level

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