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Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core

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Research-grade retatrutide is most commonly available in 5 mg, 10 mg, 20 mg, 24 mg, and 30 mg vial sizes

grilled chicken breast (28g protein) cup cooked quinoa salad with spinach, 4-5 small cherry tomatoes, and a lemon vinaigrette (5g protein, 2g fiber) cup steamed zucchini (1g protein, 1g fiber) Total: 34g of protein, 3g of fiber Afternoon snack4:30 PM Unjury Protein Water (20g protein) cup of mixed nuts (5g protein, 3g fiber) Total: 25g of protein, 3g of fiber Dinner7 PM 4 oz
