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To be considered eligible, patients must have: A Body Mass Index (BMI) of 40 or greater, and Four or more of the following diagnosed health conditions: o Type 2 diabetes o Hypertension (high blood pressure) o Cardiovascular disease (including heart disease or stroke) o Obstructive sleep apnoea o Dyslipidaemia (high cholesterol) Currently, very few patients meet these criteria

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Ophthalmology 120 , 23672376 (2013)

Tips for Managing Side Effects at Higher Doses To minimize side effects, gradual dose increases are recommended

Additionally, incretins seem affect the vagus nerve in the central nervous system (CNS) to decrease GI motility decelerating gastric emptying [12]