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Activation of GLP-1R also triggers the PI3K/Akt signaling pathway via the subunits of G proteins, thereby promoting -cell viability and replicative capacity ( 2.2 Inflammation and immune modulation Recent preclinical studies have demonstrated its bidirectional immunomodulatory effects, including improvement of organ dysfunction, regulation of immune responses, and mitigation of sepsis-associated cytokine storms, mediated through anti-inflammatory and anti-apoptotic pathways

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These two peptides (GLP-1 and GIP) potentiate glucose-stimulated insulin secretion in an additive manner, likely contribute equally to the incretin effect and together can fully account for the majority of the incretin effect in humans

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