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The effects of delayed gastric emptying may further compound the risk factors harbored by the obese, diabetic patient: Gastroparesis secondary to diabetes-related autonomic dysfunction Bowel dysmotility from opioids (chronic pain) and prolonged bed-rest Altered oesophageal-gastric anatomy from bariatric surgery Gastric insufflation from overzealous bag-valve ventilation with high PEEP and difficult airway Reduced efficacy of routine antiemetic regime Nausea and vomiting are reported by approximately 50% of patients using GLP-1 agonists, as direct results of reduced gastric motility and activation of central satiety centers

The behavioral specificity, sex translatability, and anatomical precision observed across studies underscore the therapeutic potential of GLP-1based interventions for nicotine use disorder

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A pharmacokinetic study examining oral semaglutide, a related GLP-1 medication , found that levothyroxine exposure increased by approximately 33% when the two drugs were taken together

Overall, 10 studies (13%) had a high risk of bias