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The research fueling these claims includes studies that found semaglutide users may face a significantly higher risk of developing NAION compared to patients using other medications

DeFronzo RA, Triplitt C, Qu Y, Lewis MS, Maggs D, Glass LC

Why did the other interventions result in prolonged weight loss periods with plateaus well after 12 months

Forcing yourself to finish the entire fruit can trigger nausea, vomiting, or gastrointestinal discomfort, so stopping when satisfied is essential
So it was a kind of off-target observation when it was used for individuals with diabetes to then start studying it for obesity
