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BMI below 25 (normal weight)

This high cost fuels demand for cheaper, compounded versions from unregulated pharmacies

Separately, rapid facial fat loss can change the proportional relationship between the face and teeth, teeth may look more prominent in some cases, or the smile framework may appear less supported, creating an aesthetic impression of shrinkage or misalignment

Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization

OASIS trials: establishing effective doses Phase 2 OASIS 1 findings: Tested multiple dose levels: 0.3mg, 0.6mg, 1.2mg, 2.4mg, 4.5mg weekly Duration: 26 weeks Primary endpoint: Weight loss at each dose Dose-response results: 0.3mg weekly: ~4% body weight loss 0.6mg weekly: ~6% body weight loss 1.2mg weekly: ~8% body weight loss 2.4mg weekly: ~10% body weight loss 4.5mg weekly: ~12% body weight loss Key insight: Clear dose-response relationship