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The treatment, which lasts up to 45 minutes, requires little downtime

Important considerations include: Potential interactions with hormonal contraceptives (particularly with tirzepatide and exenatide) Pregnancy planning (GLP-1 medications require discontinuation before conceptiontypically 2 months for semaglutide and 1 month for tirzepatide) Management of gastrointestinal side effects that might overlap with endometriosis symptoms Some hormonal therapies for endometriosis can affect weight, and addressing metabolic health may be a separate but important consideration

Liraglutide showed similar benefits in the LEADER trial

The sublingual version typically comes in concentrations ranging from 1 mg/mL to 5 mg/mL, with daily doses usually starting at 0.5-1 mg and escalating over several weeks