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Long-term PPI use (beyond 8-12 weeks) may reduce B12 and magnesium absorption, nutrients already affected by semaglutide's impact on the GI tract

Some patients, termed super-responders, lose more weight than expected

Mima A, Gotoda H, Lee R, Murakami A, Akai R, Lee S

Research shows that people who stop a GLP-1 after losing weight often regain weight within a year

The PI3K/Akt signaling axis and type 2 diabetes mellitus (T2DM): From mechanistic insights into possible therapeutic targets
