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This is the first trial to demonstrate the cardiovascular benefits of semaglutide in patients with preexisting CVD and overweight or obesity but without T2DM

However, two meta-analyses of these studies demonstrated an 80% increased risk of acute pancreatitis in patients using DPP-4 inhibitors compared with those receiving standard care (278,279)

Five studies focused specifically on the role of GLP-1 in diabetic neuropathy [46,47,48,49,50]

The exact storage procedure of retatrutide is still unknown, but it will most likely follow the same required storage conditions as other weight loss injections