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While compounded GLP-1s include the same active ingredient as brand-name GLP-1s, they are not approved by the FDA

Semaglutide is recommended as an option: As monotherapy when metformin is contraindicated or not tolerated, or In dual or triple therapy combinations when a GLP-1 receptor agonist is appropriate (for example, when further glucose control is needed and weight loss would be beneficial, or when other treatments are unsuitable)

This is particularly beneficial for individuals with obesity who also have diabetes or prediabetes

4 Discussion The two current trials investigated the safety and pharmacokinetics of the novel human GLP-1 analogue oral semaglutide during ascending single and multiple dosing

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