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Dopamine signaling in the dorsal striatum is essential for motivated behaviors: lessons from dopamine-deficient mice

At standard low doses used for diabetes, the pill often results in less weight loss than the high-dose injections

These medications appear to suppress hunger signals and alter the brain's response to food or other rewards

Many immune cells, including macrophages, monocytes, eosinophils, and lymphocytes, express GLP-1 receptors

Again, there is minimal research on microdosing, but proponents tout a few potential perks: Milder side effects: Ozempic, Zepbound, and other similar medications can cause gnarly gut issues (nausea, vomiting, diarrhea)