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Although these data demonstrate the potential for targeted remodeling of neurons expressing the GLP-1 receptor to treat obesity, these preclinical findings must be evaluated in humans

Mojola Omole, a breast surgical oncologist at the Scarborough Health Network in Toronto, who wasn't involved in the recent wave of GLP-1 cancer research

Mild itchiness at the injection site is a common side effect that can last for a day or two

Potential direct mechanisms involve GLP-1 receptor activation on vascular endothelial cells and possibly immune cells, though human evidence for the latter is variable