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Jennifer Manne-Goehler, an infectious disease and obesity specialist at Brigham and Womens Hospital in Boston, tells TODAY.com

And none of the big GLP-1 trials studied anything like microdosing. So right away, if youre going off-label, youre stepping into the unknown. Heres a quick rundown of what might drive someone to try a less-is-more approach: Cost concerns: Depending on your insurance (or lack thereof), these medications can be pricy

Another semaglutide side effect: Stomach paralysis

The guidance also highlights major hurdles, including high cost, limited supply and uneven access around the world

Constipation and other GI symptoms Slowed gastric motility does not just affect the stomach
