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Description
Sleeman, J
Dimensionality reduction of the integrated data set was performed by principal component analysis (PCA)
& Marshall, G
High resolution cellular localization of the GLP-1R in monkey pancreas, gastrointestinal, cardiac and renal tissues was revealed by immunohistochemistry using the mAb 3F52 and importantly the specificity was proven by use of in situ ligand binding showing the same expression pattern
Clinical trials are now underway in patients with obesity using these mAbs in combination with GLP1-receptor agonists to explore this important possibility (www.clinicaltrials.gov, NCT06299098)
