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281 Clinical evidence further indicates organ-specific anti-aging effects: semaglutide treatment in individuals with HIV-associated lipohypertrophy resulted in an approximate 3.1-year reduction in biological age, primarily through improvements in the immune/inflammatory system and the brain

Findings from a 4-day Alternaria alternata extract intranasal challenge model showed that the absence of GLP-1R/glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling exacerbated airway inflammation, characterized by increased lung ILC2s, lymphocytes, eosinophils, and neutrophils, as well as heightened pulmonary expression of type 2 cytokines (IL-5, IL-13), chemokines (CCL11, CCL24), and epithelial ICAM-1