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Post-marketing reports of adverse reactions with oral progesterone include facial edema, circulatory collapse, congenital heart disease, hypertension, hypotension, and sinus tachycardia

The drug has mild side effects, such as hypertrichosis, or excessive hair growth, and hyperglycemia

A., & Seufert, J

Moreover, although we applied the PRISMA framework and screened studies systematically, the body of available evidence included heterogeneous study types, ranging from randomized controlled trials and observational studies to animal experiments and narrative reviews
