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The cost of diabetes care-an elephant in the room

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The paper Association between eating behavior patterns and the therapeutic efficacy of GLP-1 receptor agonists in individuals with type 2 diabetes: a multicenter prospective observational study was authored by Yuya Koide, Takehiro Kato, Makoto Hayashi, Hisashi Daido, Takako Maruyama, Takuma Ishihara, Kayoko Nishimura, Shin Tsunekawa, and Daisuke Yabe on behalf of G-DIET Investigators

Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges. International Journal of Molecular Sciences 24: 7287

It is currently unclear if the resistance to GLP-1 is primarily due to impaired receptor expression, reduced signaling in the gut-brain axis and/or intestinal dysbiosis