glp-1 receptor agonists for type 2 diabetes GLP-1-based therapies diabetes: from single, dual and triple to endogenous production and L-cell differentiation | Diabetology & Metabolic Syndrome glp-1_analogs [TUSOM | Pharmwiki]
Description
J Neurosci (2012) 32(40):137018
![glp-1 receptor agonists for type 2 diabetes GLP-1-based therapies diabetes: from single, dual and triple to endogenous production and L-cell differentiation | Diabetology & Metabolic Syndrome glp-1_analogs [TUSOM | Pharmwiki]](https://tmedweb.tulane.edu/pharmwiki/lib/exe/fetch.php/glp1.png?w=600&tok=baf39c)
Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
![glp-1 receptor agonists for type 2 diabetes GLP-1-based therapies diabetes: from single, dual and triple to endogenous production and L-cell differentiation | Diabetology & Metabolic Syndrome glp-1_analogs [TUSOM | Pharmwiki]](https://www.datocms-assets.com/92605/1713817602-featured-image.png?auto=format&q=65)
But coverage changes
![glp-1 receptor agonists for type 2 diabetes GLP-1-based therapies diabetes: from single, dual and triple to endogenous production and L-cell differentiation | Diabetology & Metabolic Syndrome glp-1_analogs [TUSOM | Pharmwiki]](https://cdn.rcsb.org/pdb101/motm/311/peptide_agonists.png)
This was a randomized, double-blind study with three arms of treatment: placebo and liraglutide 1.8 and 3.0 mg
![glp-1 receptor agonists for type 2 diabetes GLP-1-based therapies diabetes: from single, dual and triple to endogenous production and L-cell differentiation | Diabetology & Metabolic Syndrome glp-1_analogs [TUSOM | Pharmwiki]](https://www.researchgate.net/publication/383495995/figure/fig1/AS:11431281459381455@1748120716657/Glucagon-like-peptide-1-receptor-agonist-GLP-1RA-mechanisms-of-action-in-type-2.png)
Animal research indicates semaglutide has low passage into lactation fluid due to its large peptide size
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