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PYY is another candidate for the short-term control of food intake (64, 65) that originates from the L-cells in the ileal and colon mucosa following stimulation by feeding, particularly when ingested nutrients, namely fatty acids, reach the distal portion of the small bowel and colon (66)
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The trials show the same thing: people carrying extra weight and living with heart failure did not just shrink on these drugs, they felt better and walked farther (Kosiborod, New England Journal of Medicine, 2023)

The higher concentration means smaller injection volumes, which some researchers prefer

Increased fatty acid oxidation Glucagon drives the breakdown of fat stores for energy
