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That is one of the unresolved tensions in rare disease drug development

Vittone F, Liberman A, Vasic D, Ostertag R, Esser M, Walcher D, Ludwig A, Marx N, Burgmaier M: Sitagliptin reduces plaque macrophage content and stabilises arteriosclerotic lesions in Apoe (/) mice

Moreover, Pontes-da-Silva et al

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GLP-1 GLP-1 is secreted by the pancreas and by intestinal L-cells in response to glucose-induced insulin release (177, 178)
