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Description
Nausea was often reported during dose escalation, with 1017% 6 of participants discontinuing treatment across dose cohorts due to GI symptoms
Because human phenotyping studies have not demonstrated clear mechanisms as to how GLP-1 receptor agonists improve kidney outcomes, a reduction in kidney inflammation that is difficult to measure in humans remains a leading candidate mechanism
In comparison, 5% of patients experienced heartburn with Wegovy 2.4 mg in clinical trials
Reduction in vascular inflammation may contribute to these cardioprotective effects
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