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Notwithstanding these limitations, disproportionality analysis still remains a crucial tool for detecting potential safety signals associated with drugs and guiding further investigations [Reference Chen, Ding, Fu and Xiao16, Reference Zhou, Peng, Lin, Jiang, Peng and Gu29, Reference Blau, Tella, Taylor and Rother33, Reference Ding, Chen, Yang, Fang, Cao and Liu52]

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Glucagon-like peptide 1 receptor agonists for type 2 diabetes, Diabetes Spectrum (2017) With Trulicity, patients may be able to lose some weight, Eli Lilly Efficacy and Safety of Dulaglutide 3.0 mg and 4.5 mg Versus Dulaglutide 1.5 mg in Metformin-Treated Patients With Type 2 Diabetes in a Randomized Controlled Trial (AWARD-11), Diabetes Care (2021) Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial, Lancet Diabetes Endocrinology (2017) Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial, Lancet (2014) Efficacy and safety of dulaglutide monotherapy versus metformin in type 2 diabetes in a randomized controlled trial (AWARD-3), Diabetes Care (2014) Mounjaro prescribing information, Eli Lilly Beyond glycemia: Comparing tirzepatide to GLP-1 analogues, Reviews in Endocrine and Metabolic Disorders (2023) Efficacy and safety of tirzepatide monotherapy compared with dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono): a double-blind, multicentre, randomised, phase 3 trial, Lancet Diabetes Endocrinology (2022) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice

The drugs' makers, Novo Nordisk and Eli Lilly, excluded people who were pregnant or planned to become pregnant from their clinical trials, a common practice when testing new medicines