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Therefore, exploring the recognition mechanism between GLP-2 and GLP-2R is of interest for further understanding the mechanism of ligand recognition and receptor activation among class B GPCRs

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We found that exendin-phe1 favored G protein signaling, whilst exendin-asp3 favored -arrestin recruitment

For patients with diagnosed irritable bowel syndrome, a low-FODMAP diet might be considered, but only under the guidance of a dietitian