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Our findings indicate that the formation of a single stable oligomer in freshly prepared solutions, as is the case for semaglutide-Am (GLP-1-Am (20, PEG2-PEG2--Glu-stear)), results in the greatest physical stability of all the analogues and its lower propensity for aggregation, as opposed to the analogues for which diverse oligomeric states are populated, which aggregate into different species
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