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A GM imbalance may inhibit the differentiation of the Tregs subpopulation, leading to the predominant differentiation of Th17 cells, which belong to the CD4 + T-cell osteoblastic cell group and can secrete IL-17a, IL-1, IL-6, tumor necrosis factor, and low levels of interferon-

Int J Obes 38(5):689697 Aroda VR et al (2023) Safety and tolerability of semaglutide across the SUSTAIN and PIONEER phase IIIa clinical trial programmes

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