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Description
Gastrin releasing peptide stimulates the secretion of insulin, but not that of glucagon or somatostatin, from the isolated perfused dog pancreas

doi: 10.1016/j.ijpharm.2023.123718

A GLP-1-only plan targets one pathway related to appetite and digestion, while GIP + GLP-1 targets two pathways that may enhance metabolic response and insulin sensitivity for some people
Eating too little can create an unpredictable metabolism because your body cannot establish a consistent energy baseline

Furthermore, concomitant agonism of other nutrient-stimulated hormones, such as gastric inhibitory polypeptide (GIP) and glucagon (GCG), increase the central anorectic effect [8]
