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Clinical evidence shows that single agents with dual-receptor activitylike tirzepatide (GIP + GLP-1 agonist)produce greater weight loss than GLP-1 alone, and they maintain a cleaner safety profile than managing two separate medications

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Furthermore, the vagotomy surgical procedure blocks the suppressive effects of intraperitoneal (IP) GLP-1 [55,56], suggesting a parasympathetic-nervous-system-dependent effect of GLP-1

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