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The landmark SELECT trial significantly expanded the therapeutic paradigm by demonstrating a 20% relative risk reduction in three-point major adverse cardiovascular events (MACEs) with semaglutide 2.4 mg in 17,604 patients with obesity but without diabetes, leading to FDA approval for cardiovascular risk reduction in March 2024 [82]

Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: A randomized, double-blind study

Weeks 9-12 (7.5mg): Appetite reduction deepens

There are other mechanisms by which circulating incretin mimetics can influence deep brain function without crossing the blood-brain barrier

These medications were originally developed to manage diabetes