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Depletion of luminal Na+ did not affect l-valine-induced GLP-1 secretion (P>0.05), suggesting that co-transport of l-valine and Na+ is not important for the depolarization necessary to activate the voltage-gated Ca2+-channels
Use of blockbuster anti-obesity drugs like Wegovy and Zepbound is growing, with about 1 in 8 adults in the U.S
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GLP-1 receptor agonists can reduce thirst signals and increase fluid loss through gastrointestinal changes, making intentional hydration critical during treatment
