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It is not recommended for anyone with a personal or family history of medullary thyroid carcinoma or those with multiple endocrine neoplasia syndrome type 2

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The initiation of metformin in such patients should not forego or delay the initiation of evidence-based SGLT2 inhibitors or GLP-1RAs

Originally used for Type 2 diabetes, these medications are being repurposed for a wider range of health conditions, prompting an evolution in chronic disease treatment paradigms

Potential neuroprotective and autophagy-enhancing effects of alogliptin on lithium/pilocarpine-induced seizures in rats: Targeting the AMPK/SIRT1/Nrf2 axis
