retatrutide mechanism gip glp-1 glucagon triple agonist Demonstrated metabolic effects of GIP, and GCG agonism as mono, PDB-101: Molecule of the Month:
Description
Lancet 403 , 16351648 (2024)
GIP showed a diminished effect in boosting insulin secretion in T2D patients, for reasons that are still not understood
Knowing this arc prevents discouragement during the slow early weeks and sets appropriate expectations for when the most dramatic changes will appear
risks of continuing the GLP-1 if IBS symptoms become challenging
FDA-approved branded medications like Wegovy and Zepbound cost significantly more than compounded alternatives
