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In Phase 2 clinical trials, gastrointestinal side effects like nausea (28% of patients) and diarrhea (24%) peaked at weeks 6-8, then substantially resolved by week 12

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While semaglutide is generally safe, it can cause some side effects, so its important to use it under the guidance of a healthcare provider

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This effect correlates with the thermogenic component, as increased metabolic rate often accompanies increased heart rate