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AGEs are also able to cross-link with collagen and elastin fibers resulting in the stiffening of the tissue [26]

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Network dose-response meta-analysis estimates by dose, and nonparametric monotonic increasing model plots were employed to assess the trends in adverse effects with increasing doses

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The seven-week-old male C57BL/KSJ diabetic db/db and db/m mice were housed in an ambient temperature of 21 2 C and humidity of 45 10%, maintained under a 12 h light/dark cycle