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Smoking accelerates alveolar bone loss, masks gingival inflammation, and raises implant failure rates
However, some research has examined transitioning from high-dose tirzepatide to retatrutide as a sequential approach

However, we noticed moderate-to-high heterogeneity, peaking at 12 months ( I 2 = 77.1%), mostly due to the evident sample size difference in Azzam et al., 17 and other variabilities between studies (Figure 3)

Tirzepatide is FDA-approved (for diabetes and weight loss, depending on the brand) and works as a dual-agonist, targeting GLP-1 and GIP receptors to reduce appetite, improve insulin response, and support weight loss

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