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Conversely, in sorafenib-treated HCC cells, overexpression of the sigma-1 receptor (S1R) reduces oxidative stress via modulation of the NRF2 pathway and system Xc , conferring ferroptosis resistance (127, 128)

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Why is the FDA allowing it

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Several mechanisms may potentially contribute to blood pressure effects, including: weight loss (a well-established factor in blood pressure reduction), possible promotion of natriuresis (sodium excretion by the kidneys), and theoretical improvements in endothelial functionthough many of these mechanisms remain hypothetical rather than definitively proven