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Further studies are needed to assess the potential problem of increased inflammation caused by elevated NAD+ levels and to clarify the role of NAD+ in SASP regulation and mechanisms of regulation of CD38 expression in aging tissues

Potential Side Effects: Transient mild increases in cortisol and ACTH (typically not clinically significant) [18]

This approach theoretically allows the body to adjust more slowly to changing medication levels and provides time to strengthen lifestyle habits while maintaining some medication support, though specific research on this approach is limited

The consistency across diverse populations, different ethnicities, across all countries, not just Canada, varying baseline weights, and both diabetic and non-diabetic participants all experienced meaningful improvements