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After several months of weekly 24-hour advances, you could inadvertently shift into a six-day cycle instead of seven, raising side effect risks

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10.1146/annurev.pharmtox.48.113006.094646

Whether this is clinically beneficial depends on the context (more on this here) Hyperkalemic cardiac arrest or peri-arrest Hyperkalemia should be strongly suspected in patients with cardiac arrest, especially when the risk factors associated with development of hyperkalemia are present
Never use the vial if you accidentally freeze it
